6 Patterns > Fibrosis Pattern > Additional Features > w/ Airway-Centered Fibrosis

Fibrosis w/ Airway-Centered Fibrosis

 

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Chronic aspiration

Pneumoconiosis

Smoking/Inhalational 

Other Considerations:

  • Chronic Allograft Rejection

  • Chronic Recurrent Infection

  • Idiopathic Airway Centered Fibrosis

Connective Tissue Disease

Chronic Hypersensitivity Pneumonitis

Sample Signout

If no additional specific histologic features are identified, consider the following approach to signing the case out:

Airway centered fibrosing Interstitial pneumonia (see comment).

Comment:  The biopsy shows advanced fibrosis with architectural distortion with an airway centered distribution. The differential diagnosis includes chronic inhalational injury such as chronic hypersensitivity pneumonitis, CTD-ILD, chronic aspiration (which could be sub-clinical), chronic rejection, pneumoconioses, recurrent infection, and as an idiopathic disease.  No additional specific histologic features to indicate an etiology are identified.  The diagnosis of ILD requires a multidisciplinary approach.  Correlation with imaging studies and clinical history is suggested.