6 Patterns > Fibrosis Pattern > Additional Features
Fibrosis Sub-Patterns
There are 7 sub-patterns in the setting of fibrosis.
Click the image most similar to your case. It may be OK to see more than one pattern.
w/ Variable involvement
UIP/IPF
Connective Tissue Disease
Chronic Hypersensitivity Pneumonitis
Pneumoconiosis
Others (rare)
w/ Diffuse alveolar wall fibrosis
Idiopathic NSIP
Connective Tissue Disease
Drug toxicity
Pneumoconiosis
Smoking related interstitial fibrosis
Chronic Hypersensitivity Pneumonitis
Healed acute lung injury
Immunodeficiency disease
w/ Granulomas
Chronic Hypersensitivity Pneumonitis
Sarcoidosis/Berylliosis
Certain chronic infections
Chronic Aspiration
w/ Honeycomb Only
If diffuse disease on CT, UIP and others
If focal disease on CT, middle lobe, post infectious, aspiration, etc.
w/ Airway-centered distribution
Chronic Hypersensitivity Pneumonitis
Chronic aspiration
Adverse drug reaction
Connective Tissue Disease
Smoking/inhalational
Chronic/recurrent infection
Idiopathic disease
w/ Pleuritis and/or lymphoid hyperplasia
Connective Tissue Disease
w/ acute lung injury
Acute exacerbation of underlying ILD
Sample Signout of the Fibrotic Pattern
If no additional specific histologic features are identified, consider the following approach to signing the case out:
Fibrosing Interstitial pneumonia (see comment).
Comment: The biopsy shows advanced fibrosis with architectural distortion. No additional specific histologic features to indicate an etiology are identified. There is a broad differential diagnosis including UIP, advanced NSIP, chronic HP, and CTD-associated ILD among others. The diagnosis of ILD requires a multidisciplinary approach. Correlation with imaging studies and clinical history is suggested.